Recent Publications


Devenyi R, Ortega F, Groenendaal W, Krogh-Madsen T, Christini D, Sobie E. Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility. J Physiol. October 2016. [PubMed]
Brown T, Krogh-Madsen T, Christini D. Illuminating Myocyte-Fibroblast Homotypic and Heterotypic Gap Junction Dynamics Using Dynamic Clamp. Biophys J. 2016;111(4):785-797. [PubMed]
Krogh-Madsen T, Sobie E, Christini D. Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms. J Physiol. 2016;594(9):2525-2536. [PubMed]
Groenendaal W, Ortega F, Kherlopian A, Zygmunt A, Krogh-Madsen T, Christini D. Cell-specific cardiac electrophysiology models. PLoS Comput Biol. 2015;11(4):e1004242. [PubMed]
Brown T, Krogh-Madsen T, Christini D. Computational Approaches to Understanding the Role of Fibroblast-Myocyte Interactions in Cardiac Arrhythmogenesis. Biomed Res Int. 2015;2015:465714. [PubMed]
Groenendaal W, Ortega F, Krogh-Madsen T, Christini D. Voltage and calcium dynamics both underlie cellular alternans in cardiac myocytes. Biophys J. 2014;106(10):2222-2232. [PubMed]
Maoz A, Christini D, Krogh-Madsen T. Dependence of phase-2 reentry and repolarization dispersion on epicardial and transmural ionic heterogeneity: a simulation study. Europace. 2014;16(3):458-465. [PubMed]
Hu Z, Kant R, Anand M, et al. Kcne2 deletion creates a multisystem syndrome predisposing to sudden cardiac death. Circ Cardiovasc Genet. 2014;7(1):33-42. [PubMed]
Ortega F, Butera R, Christini D, White J, Dorval A. Dynamic clamp in cardiac and neuronal systems using RTXI. Methods Mol Biol. 2014;1183:327-354. [PubMed]
Kant R, Hu Z, Malhotra J, et al. NHE isoform switching and KChIP2 upregulation in aging porcine atria. PLoS One. 2013;8(12):e82951. [PubMed]
Bot C, Kherlopian A, Ortega F, Christini D, Krogh-Madsen T. Rapid genetic algorithm optimization of a mouse computational model: benefits for anthropomorphization of neonatal mouse cardiomyocytes. Front Physiol. 2012;3:421. [PubMed]
Heerdt P, Kant R, Hu Z, et al. Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy. J Mol Cell Cardiol. 2012;53(3):350-353. [PubMed]
Iravanian S, Kanu U, Christini D. A class of Monte-Carlo-based statistical algorithms for efficient detection of repolarization alternans. IEEE Trans Biomed Eng. 2012;59(7):1882-1891. [PubMed]
Sarkar A, Christini D, Sobie E. Exploiting mathematical models to illuminate electrophysiological variability between individuals. J Physiol. 2012;590(11):2555-2567. [PubMed]
Gaeta S, Christini D. Non-linear dynamics of cardiac alternans: subcellular to tissue-level mechanisms of arrhythmia. Front Physiol. 2012;3:157. [PubMed]
Krogh-Madsen T, Abbott G, Christini D. Effects of electrical and structural remodeling on atrial fibrillation maintenance: a simulation study. PLoS Comput Biol. 2012;8(2):e1002390. [PubMed]
Krogh-Madsen T, Christini D. Nonlinear dynamics in cardiology. Annu Rev Biomed Eng. 2012;14:179-203. [PubMed]
Roberts B, Christini D. The relative influences of phosphometabolites and pH on action potential morphology during myocardial reperfusion: a simulation study. PLoS One. 2012;7(11):e47117. [PubMed]
Roberts B, Christini D. NHE inhibition does not improve Na(+) or Ca(2+) overload during reperfusion: using modeling to illuminate the mechanisms underlying a therapeutic failure. PLoS Comput Biol. 2011;7(10):e1002241. [PubMed]
Moreno J, Zhu Z, Yang P, et al. A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms. Sci Transl Med. 2011;3(98):98ra83. [PubMed]